Detailed view for TVAG_334240

Basic information

TDR Targets ID: 843344
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 7.5827 | Length (AA): 342 | MW (Da): 38423 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12706   Beta-lactamase superfamily domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128466)

Species Accession Gene Product
Babesia bovis BBOV_I004470   conserved hypothetical protein
Candida albicans CaO19.6061   similar to S. cerevisiae FMP30 (YPL103C) mitochondrial protein
Candida albicans CaO19.13482   similar to S. cerevisiae FMP30 (YPL103C) mitochondrial protein
Caenorhabditis elegans CELE_Y37E11AR.3   Protein NAPE-2, isoform A
Caenorhabditis elegans CELE_Y37E11AR.4   Protein NAPE-1
Dictyostelium discoideum DDB_G0271270   beta-lactamase-like domain-containing protein
Dictyostelium discoideum DDB_G0293392   beta-lactamase-like domain-containing protein
Echinococcus granulosus EgrG_002071000   3'partial|5'partial|n acyl phosphatidylethanolamine hydrolyzing
Echinococcus granulosus EgrG_000144800   n acyl phosphatidylethanolamine hydrolyzing
Echinococcus granulosus EgrG_000124500   n acyl phosphatidylethanolamine hydrolyzing
Echinococcus multilocularis EmuJ_000144800   n acyl phosphatidylethanolamine hydrolyzing
Homo sapiens ENSG00000161048   N-acyl phosphatidylethanolamine phospholipase D
Leishmania donovani LdBPK_131290.1   Beta-lactamase superfamily domain containing protein, putative
Leishmania infantum LinJ.13.1290   hypothetical protein, conserved
Leishmania major LmjF.13.1390   hypothetical protein, conserved
Leishmania mexicana LmxM.13.1390   hypothetical protein, conserved
Mus musculus ENSMUSG00000044968   N-acyl phosphatidylethanolamine phospholipase D
Mycobacterium tuberculosis Rv0906   Conserved protein
Mycobacterium ulcerans MUL_0235   hypothetical protein
Neospora caninum NCLIV_009780   Beta-lactamase domain protein (Precursor), related
Neospora caninum NCLIV_031520   hypothetical protein, conserved
Plasmodium berghei PBANKA_0905200   conserved Plasmodium protein, unknown function
Plasmodium berghei PBANKA_1026400   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1143800   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1416300   conserved protein, unknown function
Plasmodium knowlesi PKNH_0941700   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_1341800   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_085635   hypothetical protein, conserved
Plasmodium vivax PVX_092795   hypothetical protein, conserved
Plasmodium yoelii PY06610   hypothetical protein
Plasmodium yoelii PY02609   hypothetical protein
Saccharomyces cerevisiae YPL103C   Fmp30p
Schmidtea mediterranea mk4.075769.00   N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
Schmidtea mediterranea mk4.011893.00   N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
Toxoplasma gondii TGME49_320490   N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D family protein
Toxoplasma gondii TGME49_231150   hypothetical protein
Theileria parva TP01_0189   hypothetical protein
Trichomonas vaginalis TVAG_334240   conserved hypothetical protein
Trichomonas vaginalis TVAG_453240   conserved hypothetical protein
Trichomonas vaginalis TVAG_223500   conserved hypothetical protein
Trichomonas vaginalis TVAG_290900   conserved hypothetical protein

Essentiality

TVAG_334240 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu922 Mycobacterium tuberculosis non-essential nmpdr
PBANKA_0905200 Plasmodium berghei Dispensable plasmo
TGME49_320490 Toxoplasma gondii Probably essential sidik
TGME49_231150 Toxoplasma gondii Probably essential sidik
TGME49_320490 Toxoplasma gondii Probably non-essential sidik
TGME49_231150 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus N-acyl phosphatidylethanolamine phospholipase D Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_334240 (Trichomonas vaginalis), conserved hypothetical protein
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